Undermining the endothelium by ablation of MAPK-MEF2 signaling
J. Clin. Invest. Eric N. Olson, et al. 113:1110 doi:10.1172/JCI21497 [
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Figure 1MAPK signaling pathways. Survival signals activate MEKK2/3, which activates MEK5, which activates BMK1. BMK1 stimulates the transcriptional activity of MEF2C by phosphorylating the transcription activation domain and by interacting directly with MEF2C and contributing its own transcriptional activation domain. MEF2C is required for cell survival and proliferation by activating downstream target genes that remain to be identified.
