c-Cbl–deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action
J. Clin. Invest. Juan C. Molero, et al. 114:1326 doi:10.1172/JCI21480 [Go to this article.]

Figure 4
[³H]-2-DOG uptake in isolated soleus (A) and EDL (B) muscles incubated without (Basal) or with 1.8 nM (Submax) or 60 nM (Max) insulin for 30 minutes at 30–C. (C) [³H]-2-DOG uptake in epididymal fat explants incubated without (Basal) or with 0.05 nM (Submax) or 1 nM (Max) insulin for 15 minutes at 37–C. WT mice are represented by the black bars and c-Cbl^–/– mice by the white bars. Data represent the mean ± SEM of 5–12 isolated tissues per group. *P < 0.05, **P < 0.01.