c-Cbl–deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action
J. Clin. Invest. Juan C. Molero, et al. 114:1326 doi:10.1172/JCI21480 [Go to this article.]

Figure 1
c-Cbl–deficient mice show reduced fat mass despite hyperphagia. (A and B) Body weight evolution between 4 and 16 weeks of age in WT (+/+) and c-Cbl–deficient (–/–) mice (A), and daily food intake in 12- to 16-week-old WT and c-Cbl–deficient mice (B). Data represent the mean ± SEM of 5–20 animals per group. *P < 0.05. (C–E) Representative epididymal (C) and subcutaneous inguinal (D) white fat pads and interscapular brown adipose tissue (E) from age- and weight-matched WT and c-Cbl–deficient mice. Scale bars: 1 cm. (F) Representative adipocyte size distribution from age- and weight-matched WT and c-Cbl–deficient mice.