Michael J. Owen, Nigel M. Williams, Michael C. O’Donovan
J Clin Invest.
2004;
113(9):1255–1257
doi:10.1172/JCI21470
This article Copyright © 2004, The American Society for Clinical Investigation
Abstract
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T
he gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia . Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.
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