Fat’s loss is bone’s gain
J. Clin. Invest. Liming Pei, et al. 113:805 doi:10.1172/JCI21311 [Go to this article.]

Figure 1
Model for the influence of the PPARγ pathway on osteogenesis. Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. An imbalance between the two is associated with osteoporosis. The PPARγ pathway not only determines adipocyte differentiation from mesenchymal progenitors, but also inhibits osteoblast differentiation, as revealed by Akune et al. (10). This new finding raises the possibility of interrupting the PPARγ pathway for the treatment of osteoporosis.