Sculpting organ innervation
J. Clin. Invest. Barbara L. Hempstead, et al. 113:811 doi:10.1172/JCI21309 [Go to this article.]

Figure 1
Distinctive pairing of endothelins and neurotrophic factors promotes target innervation during development. Although the sequential action of ET-1 to induce myocyte production of NGF is suggested to promote sympathetic innervation of the heart, more complex interactions of ET-3 and GDNF occur in the patterning of the enteric nervous system.