Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
J. Clin. Invest. Tirumalai Rangasamy, et al. 114:1248 doi:10.1172/JCI21146 [
Go to this article.]
Figure 7Validation of microarray data by Northern blot and enzyme assays. (
A) Analysis of mRNA levels of NQO1, GCLm, GST-α1, HO-1, TrxR, Prx-1, GSR, and G6PDH in the lungs of
Nrf2+/+ and
Nrf2–/– mice exposed to either air or CS (
n = 3 per group). (
B) Effect of CS on the specific activities of selected enzymes in the lungs of
Nrf2+/+ and
Nrf2–/– mice. Values represent mean ± SE (
n = 3 per group). *
P – 0.05 vs. control of the same genotype.
