Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
J. Clin. Invest. Tirumalai Rangasamy, et al. 114:1248 doi:10.1172/JCI21146 [
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Figure 1Increased susceptibility of
Nrf2–/– mice to CS-induced emphysema. Shown are H&E-stained lung sections from
Nrf2+/+ and
Nrf2–/– mice exposed to air alone (
A and
B,
E and
F, and
I and
J) and to CS (
C and
D,
G and
H, and
K and
L) at the indicated times. Sections from the air-exposed
Nrf2+/+ and
Nrf2–/– mice show normal alveolar structure (
n = 5 per group). Lung sections from the CS-treated (6 months)
Nrf2–/– mice show increased air space enlargement when compared with the lung sections from the CS-treated
Nrf2+/+ mice. Original magnification, ×20.
