Advertisement

Citations to this article

Abstract

Although inflammation and protease/antiprotease imbalance have been postulated to be critical in cigarette smoke–induced (CS-induced) emphysema, oxidative stress has been suspected to play an important role in chronic obstructive pulmonary diseases. Susceptibility of the lung to oxidative injury, such as that originating from inhalation of CS, depends largely on its upregulation of antioxidant systems. Nuclear factor, erythroid-derived 2, like 2 (Nrf2) is a redox-sensitive basic leucine zipper protein transcription factor that is involved in the regulation of many detoxification and antioxidant genes. Disruption of the Nrf2 gene in mice led to earlier-onset and more extensive CS-induced emphysema than was found in wild-type littermates. Emphysema in Nrf2-deficient mice exposed to CS for 6 months was associated with more pronounced bronchoalveolar inflammation; with enhanced alveolar expression of 8-oxo-7,8-dihydro-2′-deoxyguanosine, a marker of oxidative stress; and with an increased number of apoptotic alveolar septal cells — predominantly endothelial and type II epithelial cells — as compared with wild-type mice. Microarray analysis identified the expression of nearly 50 Nrf2-dependent antioxidant and cytoprotective genes in the lung that may work in concert to counteract CS-induced oxidative stress and inflammation. The responsiveness of the Nrf2 pathway may act as a major determinant of susceptibility to tobacco smoke–induced emphysema by upregulating antioxidant defenses and decreasing lung inflammation and alveolar cell apoptosis.

Authors

Tirumalai Rangasamy ... Rubin M. Tuder, Shyam Biswal

×

Total citations by year

Year: 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 32 39 30 27 33 23 35 17 21 5 262
Citation information

Citations to this article (262)

Title and authors Publication Year
NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation
JH Kim, RK Thimmulappa, V Kumar, W Cui, S Kumar, P Kombairaju, H Zhang, J Margolick, W Matsui, T Macvittie, SV Malhotra, S Biswal
Journal of Clinical Investigation 2014
Tobacco Smoke–Induced Lung Fibrosis and Emphysema
D Morse, IO Rosas
Annual Review of Physiology 2014
Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance
AI Rojo, G McBean, M Cindric, J Egea, MG López, P Rada, N Zarkovic, A Cuadrado
Antioxidants & Redox Signaling 2014
Ascorbic acid deficiency affects genes for oxidation–reduction and lipid metabolism in livers from SMP30/GNL knockout mice
K Takahashi, Y Kishimoto, T Konishi, Y Fujita, M Ito, K Shimokado, N Maruyama, A Ishigami
Biochimica et Biophysica Acta (BBA) - General Subjects 2014
Heme Oxygenase-1 As a Target for Drug Discovery
R Motterlini, R Foresti
Antioxidants & Redox Signaling 2014
Pathological changes in the COPD lung mesenchyme – Novel lessons learned from in vitro and in vivo studies
O Ojo, AL Lagan, V Rajendran, A Spanjer, L Chen, SS Sohal, I Heijink, R Jones, H Maarsingh, TL Hackett
Pulmonary Pharmacology & Therapeutics 2014
Carbocisteine Reduces Virus-Induced Pulmonary Inflammation in Mice Exposed to Cigarette Smoke
Y Yageta, Y Ishii, Y Morishima, S Ano, S Ohtsuka, M Matsuyama, K Takeuchi, K Itoh, M Yamamoto, N Hizawa
American journal of respiratory cell and molecular biology 2014
CURRENT KNOWLEDGE AND TRENDS IN AGE-RELATED MACULAR DEGENERATION: Genetics, Epidemiology, and Prevention
R Velez-Montoya, SC Oliver, JL Olson, SL Fine, H Quiroz-Mercado, N Mandava
Retina 2014
Keap1 inhibition attenuates glomerulosclerosis
Y Miyazaki, A Shimizu, I Pastan, K Taguchi, E Naganuma, T Suzuki, T Hosoya, T Yokoo, A Saito, T Miyata, M Yamamoto, T Matsusaka
Nephrology Dialysis Transplantation 2014
Oxidative stress-induced autophagy: Role in pulmonary toxicity
R Malaviya, JD Laskin, DL Laskin
Toxicology and Applied Pharmacology 2014
Animal models of chronic obstructive pulmonary disease
M Fricker, A Deane, PM Hansbro
Expert Opinion on Drug Discovery 2014
p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium
L Wang, M Cano, JT Handa
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2014
Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells
M Narasimhan, J Hong, N Atieno, VR Muthusamy, CJ Davidson, N Abu-Rmaileh, RS Richardson, AV Gomes, JR Hoidal, NS Rajasekaran
Free Radical Biology and Medicine 2014
Green tea diet decreases PCB 126-induced oxidative stress in mice by up-regulating antioxidant enzymes
BJ Newsome, MC Petriello, SG Han, MO Murphy, KE Eske, M Sunkara, AJ Morris, B Hennig
The Journal of Nutritional Biochemistry 2014
Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation
ST Mathew, P Bergström, O Hammarsten
Toxicology and Applied Pharmacology 2014
1,4-Naphthoquinone, a pro-oxidant, suppresses immune responses via KEAP-1 glutathionylation
L Gambhir, R Checker, M Thoh, RS Patwardhan, D Sharma, M Kumar, SK Sandur
Biochemical Pharmacology 2014
Role of Oxidative Stress in Chronic Diseases
P Kirkham, P Barnes
Role of Oxidative Stress in Chronic Diseases 2014
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
V Pekovic-Vaughan, J Gibbs, H Yoshitane, N Yang, D Pathiranage, B Guo, A Sagami, K Taguchi, D Bechtold, A Loudon, M Yamamoto, J Chan, GT van der Horst, Y Fukada, QJ Meng
Genes & development 2014
Recent advances in pre-clinical mouse models of COPD
R Vlahos, S Bozinovski
Clinical Science 2014
Linalool attenuates lung inflammation induced by Pasteurella multocida via activating Nrf-2 signaling pathway
Q Wu, L Yu, J Qiu, B Shen, D Wang, LW Soromou, H Feng
International Immunopharmacology 2014
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
A Cleasby, J Yon, PJ Day, C Richardson, IJ Tickle, PA Williams, JF Callahan, R Carr, N Concha, JK Kerns, H Qi, T Sweitzer, P Ward, TG Davies
PloS one 2014
Modelos animales de enfermedad pulmonar obstructiva crónica
S Pérez-Rial, Á Girón-Martínez, G Peces-Barba
Archivos de Bronconeumología 2014
Inhalation Toxicology, Third Edition
S Kelsen
Inhalation Toxicology, Third Edition 2014
Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis
ZY Zhang, C Li, C Zug, HJ Schluesener
PloS one 2014
Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis
ZY Zhang, C Li, C Zug, HJ Schluesener, J Padmanabhan
PloS one 2014

Advertisement
Advertisement