Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells
J. Clin. Invest. Vishwa Deep Dixit, et al. 114:57 doi:10.1172/JCI21134 [
Go to this article.]
Figure 2Ghrelin receptors are expressed on human monocytes. (
A) Human PBMCs were double stained with CD14 PE and GHS-R AF-488. (
B) Immunofluorescence labeling revealed GHS-R expression on cell surface of purified monocytes (upper panel); negative control failed to show any specific staining (lower panel). Ghrelin inhibits IL-1β (
C) and IL-6 (
D) secretion from LPS-treated (10 ng/ml) monocytes.
