Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes
J. Clin. Invest. Leendert A. Trouw, et al. 114:679 doi:10.1172/JCI21075 [
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Figure 8Anti-GBM and JL-1 in various genetically deficient mice. Rabbit anti–mouse GBM in combination with JL-1 was administered to either WT C57BL/6 mice or C1q
–/–, C4
–/–, C3
–/–, or FcγR
–/– mice, and albuminuria was assessed.