Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes
J. Clin. Invest. Leendert A. Trouw, et al. 114:679 doi:10.1172/JCI21075 [Go to this article.]

Figure 6
Histological changes induced by JL-1 at both the light microscopic and the electron microscopic levels. (A) Histological analysis of Silver-stained renal sections of mice injected with rabbit anti–mouse GBM and coinjected with either mAb JL-1 or IgG2b control mAb, obtained at 24 hours after injection. For JL-1–coinjected mice, images show pronounced inflammatory cell influx, focal capillary tuft occlusion by microthrombi, necrotizing lesions, nuclear debris, and wireloop-like lesions. Control-coinjected mice only display marginal inflammatory cell influx. Original magnification, ×400. (B) Quantification of histological changes using the activity index as described in Methods. (C) Electron microscopic analysis of glomerular lesions of mice injected with rabbit anti–mouse GBM and coinjected with either anti-C1q mAb JL-1 or control mAb IgG2b. At higher magnification, we observed several wireloop-like lesions in the JL-1–coinjected mice, whereas the IgG2b-coinjected mice did not display any abnormalities. Original magnifications, ×2,000 (left) and ×4,000 (right).