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Donald Y.M. Leung, Mark Boguniewicz, Michael D. Howell, Ichiro Nomura, Qutayba A. Hamid
Published in Volume 113, Issue 5
J Clin Invest. 2004; 113(5):651–657 doi:10.1172/JCI21060
Abstract | Full text | PDF
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Figure 3

Role of chemokines in AD. (A) Chemokines activated in AD versus psoriasis. (B) Representative immunostaining for immunochemical staining of a chronic AD skin section using antibody to eotaxin (left panel; original magnification, ×400), in situ hybridization of chronic AD skin for MCP-4 using a complementary RNA radio-labeled probe. The image of mRNA-cRNA complex was developed with autoradiography. Dark field illustration shows positive signal in the epidermis of inflammatory cells (middle panel; original magnification, ×400). Immunostaining of psoriasis skin section with antibody to eotaxin shows weak staining (right panel; original magnification, ×400). TARC, thymus and activation–regulated cytokine; PARC, pulmonary and activation–regulated chemokine; GROβ, growth-related β.