Steven Clarke, Fuyuhiko Tamanoi
J Clin Invest.
2004;
113(4):513–515
doi:10.1172/JCI21059
This article Copyright © 2004, The American Society for Clinical Investigation
Abstract
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rotein methylation at the C-terminus of mammalian isoprenylated proteins has been implicated in membrane attachment, protein-protein interactions, and protein stability. A new paper describes surprising results: in the absence of methylation some target proteins have increased stability, whereas others have decreased stability. The decreased stability of the RhoA protein is correlated with an increased resistance to Ras-dependent transformation and suggests the basis for the development of a new approach to antitumor therapy .
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