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Peter G.E. Kennedy
J Clin Invest. 2004;
113(4):496
doi:10.1172/JCI21052
Abstract |
Full text
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H
uman African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS HAT has unacceptable side-effects with an overall mortality of 5%. This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease.
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Total citations by year
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Citations to this article
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(12)
| Title and authors |
Publication |
Year |
Difficulties in Diagnostic Staging of Human African Trypanosomiasis
Peter G. E. Kennedy
|
J. Neuroparasitolog.
|
2011 |
Immunobiology of African trypanosomes: need of alternative interventions.
Toya Nath Baral
|
J. Biomed. Biotechnol.
|
2010 |
Anti-Anaemic Properties of the Ethanolic Extracts of Psidium guajava in Trypanosoma brucei brucei Infected Rats
O.S. Adeyemi, M.A. Akanji, J.T. Ekanem
|
Research J. of Pharmacology
|
2010 |
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
Jean Rodgers, Trevor W Stone, Michael P Barrett, Barbara Bradley, Peter G E Kennedy
|
Brain
|
2009 |
Global metabolic responses of mice to Trypanosoma brucei brucei infection.
Yulan Wang, Jürg Utzinger, Jasmina Saric, Jia V Li, Jean Burckhardt, Stephan Dirnhofer, Jeremy K Nicholson, Burton H Singer, Reto Brun, Elaine Holmes
|
Proc. Natl. Acad. Sci. U.S.A.
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2008 |
Spatially and genetically distinct African Trypanosome virulence variants defined by host interferon-gamma response.
Lorna Maclean, Martin Odiit, Annette Macleod, Liam Morrison, Lindsay Sweeney, Anneli Cooper, Peter G E Kennedy, Jeremy M Sternberg
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J INFECT DIS
|
2007 |
Parasitic central nervous system infections in immunocompromised hosts: malaria, microsporidiosis, leishmaniasis, and African trypanosomiasis.
Melanie Walker, James G Kublin, Joseph R Zunt
|
Clin. Infect. Dis.
|
2006 |
Summary of Presentations on Kinetoplastid Flagellates
SANDRA K. HALONEN, HERBERT B. TANOWITZ
|
J Eukaryotic Microbiology
|
2006 |
Human African trypanosomiasis–neurological aspects
P. G. E. Kennedy
|
J Neurol
|
2006 |
A Woman with Fever and Rash after African Safari
Daniel Z. Uslan, Kurt M. Jacobson, Neeraj Kumar, Elie F. Berbari, Robert Orenstein
|
CLIN INFECT DIS
|
2006 |
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