Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
J. Clin. Invest. Keith Syson Chan, et al. 114:720 doi:10.1172/JCI21032 [
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Figure 4Responsiveness of Stat3-deficient mice to 2-stage carcinogenesis. (
A–
C) Groups of mice (
n = 15) were treated with 25 nmol DMBA and, starting 2 weeks later, treated with twice-weekly applications of TPA (6.8 nmol) for the duration of the experiment. (
A) Percentage of mice with papillomas. (
B) Average number of papillomas per mouse. Circles, control mice; triangles, Stat3-deficient mice. (
C) Representative photograph of Stat3-deficient mice and tumor-bearing control mice at the end of the experiment shown in
A and
B.
