Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
J. Clin. Invest. Keith Syson Chan, et al. 114:720 doi:10.1172/JCI21032 [Go to this article.]

Figure 1
Response of Stat3-deficient and control mice to TPA-induced epidermal hyperproliferation. (A–D) Groups of mice (n = 3) were treated topically with 4 applications of TPA and sacrificed 24 hours after the last treatment. BrdU was injected 30 minutes prior to sacrifice. H&E staining of epidermis from (A) untreated control mice, (B) control mice treated with TPA, (C) untreated Stat3-deficient mice, and (D) Stat3-deficient mice treated with TPA. (E) Quantitation of epidermal thickness from control (white bars) and Stat3-deficient (black bars) mice treated with different doses of TPA. (F) Percentage of BrdU-positive epidermal basal cells in control (white bars) and Stat3-deficient (black bars) mice treated with different doses of TPA. Scale bar: 50 μm. **P < 0.01 by Mann-Whitney U test.