JCI - Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Mitsuhiro Watanabe, Sander M. Houten, Li Wang, Antonio Moschetta, David J. Mangelsdorf, Richard A. Heyman, David D. Moore, Johan Auwerx

Published in Volume 113, Issue 10

J Clin Invest. 2004; 113(10):1408–1418 doi:10.1172/JCI21025

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Figure 2

CA lowers hepatic TGs in KK-Ay mice. (A) Liver morphology, H&E-stained liver sections (HE), and Oil Red O_stained liver sections (OR) in animals treated with the indicated diets for 3 weeks. When sacrificed, the mice were 9 weeks old. (B) Liver TG and (C) cholesterol content after 3 weeks on the different diets (age 9 weeks, n = 5). (D) In vivo VLDL secretion from the livers of mice on the different diets (age 7 weeks, n = 4) or after treatment with GW4064 (age 12 weeks, n = 4). C, control diet; C + CA, control diet with CA; HF, high-fat diet; HF + CA, high-fat diet with CA.