JCI - Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Mitsuhiro Watanabe, Sander M. Houten, Li Wang, Antonio Moschetta, David J. Mangelsdorf, Richard A. Heyman, David D. Moore, Johan Auwerx

Published in Volume 113, Issue 10

J Clin Invest. 2004; 113(10):1408–1418 doi:10.1172/JCI21025

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Figure 1

CA lowers serum TGs in KK-Ay mice. (A) Food intake of KK-Ay mice during 1 week on the diets as described in the figure. Serum levels of TGs, total cholesterol (Chol), and FFA in KK-Ay mice after 1 week on the different diets (age 7 weeks, n = 5). Kcal, kilocalories; BW, body weight. (B) TG and cholesterol lipoprotein profiles after size-exclusion chromatography of serum pools from five animals. The quantification of the VLDL TGs is shown in an inset. (C) Serum TGs in KK-Ay (top, age 12 weeks, n = 4) and ob/ob (bottom, age 12 weeks, n = 4) mice after 0, 1, 3, and 7 days of treatment with the synthetic FXR agonist GW4064. *P < 0.05; **P < 0.01 throughout the figures.