Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions
J. Clin. Invest. Yoram Richter, et al. 113:1607 doi:10.1172/JCI21007 [
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Figure 7Effect of SB occlusion on neointimal hyperplasia in group A. (
A) Serial sections along the MB stents of one animal demonstrate the effect of SB occlusion. Blue dots at each section denote the location of the lateral wall. Insets at top and bottom show the original bifurcations in vivo on angiogram with the stent locations outlined in yellow. The stent on the SB-patent side (top) is covered by substantially more eccentrically distributed intimal hyperplasia. (
B) The average pattern (
n = 3 animals,
n = 6 bifurcations) reveals that the SB-occluded case incurs substantially less neointimal area than the SB-patent case. The difference between the two cases is most pronounced just distal to the proximal end of the stents and diminishes as one moves distally.