Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions
J. Clin. Invest. Yoram Richter, et al. 113:1607 doi:10.1172/JCI21007 [
Go to this article.]
Figure 6Lesion composition. High-magnification images of one of the sections of a chronic (14-day) lesion. A blue dot in each image denotes the location of the lateral wall. (
A) Carstairs’ fibrin stain demonstrates high concentrations of fibrin around the stent struts, particularly on the lateral wall. (
B) Smooth-muscle cell α-actin stain shows tightly packed smooth muscle inside along the lumen (inside of the hoop in
C), with areas poor in smooth-muscle cells in the crescent region on the lateral wall. (
C) Ver Hoeff’s elastin stain shows a cellular, dense region of relatively uniform thickness (inside yellow circle) and an ECM-rich, sparse crescent region located on the lateral wall. (
D and
E) False-colored enhancement of fibrin concentration (green) highlights the difference in ECM away from the struts in the flow divider (
D) and the lateral wall (
E).
