Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions
J. Clin. Invest. Yoram Richter, et al. 113:1607 doi:10.1172/JCI21007 [
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Figure 5Pattern of neointimal hyperplasia in vivo. (
A) Serial sections along a single bifurcation show the pattern of hyperplasia on an MB stent in the SB-patent case. The original bifurcation is shown inset with green lines denoting the longitudinal location of each section. A blue dot next to each section denotes the location of the lateral wall. (
B) The average pattern (
n = 11 animals) recapitulates the individual pattern. Lesions are highly eccentric, with thickness at the lateral wall reaching values 3.5 times higher than those on the flow divider wall. The difference between the two walls grows rapidly in the proximal part of the stent opposite from the SB ostium and then diminishes in the more distal sections.