Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions
J. Clin. Invest. Yoram Richter, et al. 113:1607 doi:10.1172/JCI21007 [
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Figure 1Dynamic control of model geometry. The silicone flow channel (right to left at top) is an idealized bifurcation. (
A) In the native state, the lumens are left intact. The pneumatic drivers seen on the bottom of this photo, for example, can impinge on the lumen to simulate lesions of variable eccentricity (
B) to create taper or to locally expand by controlled suction (
C). By combining several of these drivers of different shapes, sizes, and locations, one can simulate the occurrence of disease, compensation, and vascular intervention.