Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis
J. Clin. Invest. Luke J. Engelking, et al. 113:1168 doi:10.1172/JCI20978 [
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Figure 5Relative amount of various mRNAs in the livers of WT and TgInsig-1 mice subjected to fasting and refeeding. The mice used here are the same as those used in Figure
4 and Supplemental Table 2. Total RNA from the livers of mice was pooled (five mice per group) and subjected to real-time PCR quantification as described in Methods. Each value represents the amount of mRNA relative to that in the nonfasted WT mice, which is arbitrarily defined as 1. For purposes of clarity, only the fasted and refed values are shown. FDP, farnesyl diphosphate; G6PD, glucose-6-phosphate dehydrogenase; LCE, long-chain fatty acyl elongase; S1P, site-1 protease. F, fasted group; R, refed group.
