Involvement of chymase-mediated angiotensin II generation in blood pressure regulation
J. Clin. Invest. Ming Li, et al. 114:112 doi:10.1172/JCI20805 [
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Figure 4Acute mean proximal aortic blood pressure–lowering (BP-lowering) effects of infusion of 2.5 mg/kg captopril (Cap), 80 mg/kg losartan (Los), or 2.5 mg/kg captopril combined with 80 mg/kg losartan (Los + cap) in anesthetized 7-week-old MC
+/+ (left panel) and Kit
w/Kit
w-v mice (right panel). The data are maximal changes in mean blood pressure. Values are mean ± SEM, and
n = 6–10 in each group. Intra-genotype comparisons shown in the figure were made using an unpaired Student’s
t test. Inter-genotype comparisons, using an unpaired Student’s
t test, were found not to be significantly different.
