Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes
J. Clin. Invest. Vily Panoutsakopoulou, et al. 113:1218 doi:10.1172/JCI20772 [Go to this article.]

Figure 4
TCV induces CD8⁺ T suppressor cells: analysis in HSK. (A) CD8 depletion before TCV. Depletion of CD8 T cells abolishes TCV-induced protection. C.AL-20 mice were depleted of CD8 T cells by intraperitoneal injection of depleting anti-CD8 Ab (filled circles) or isotype control (filled squares) prior to TCV and ocular infection with HSV-1. A group of mice was not vaccinated for comparison (open circles). Each group consisted of ten mice. and results are representative of three independent experiments. (B) CD8 cell transfer of disease resistance. Protection can be transferred by CD8 cell transfer from vaccinated mice. C.AL-20 mice received CD8 cells from donors vaccinated with either keratogenic Vβ8⁺ C1-6 cells (filled circles) or OVA-specific V_β6⁺ O3 cells (open circles). The recipients were ocularly infected with HSV-1 (KOS) and scored for HSK. Each group consisted of ten mice, and results are representative of three independent experiments.