JCI - TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist

TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

Reiko Horai, Akiko Nakajima, Katsuyoshi Habiro, Motoko Kotani, Susumu Nakae, Taizo Matsuki, Aya Nambu, Shinobu Saijo, Hayato Kotaki, Katsuko Sudo, Akihiko Okahara, Hidetoshi Tanioka, Toshimi Ikuse, Naoto Ishii, Pamela L. Schwartzberg, Ryo Abe, Yoichiro Iwakura

Published in Volume 114, Issue 11

J Clin Invest. 2004; 114(11):1603–1611 doi:10.1172/JCI20742

Abstract | Full text | PDF

Options: View larger image (or click on image)

Figure 4

Incidence of arthritis in TNF-α-_deficient IL-1Ra^–/– mice. Incidence (A) and severity score (B) of arthritis in TNF-α_deficient IL-1Ra^–/– mice. Squares, TNF-α^+/+ IL-1Ra^–/– mice (n = 14); triangles, TNF-α^+/– IL-1Ra^–/– mice (n = 23); circles, TNF-α^–/– IL-1Ra^–/– mice (n = 23). Statistical significance between genotypes was calculated by repeated-measures ANOVA or two-way ANOVA. *P < 0.01. (C) Incidence of arthritis in TNF-α^–/– IL-1Ra^–/– (Ra^–/–) or IL-1Ra^–/– BM cell_transferred WT mice. Triangles, WT mice transferred with TNF-α^–/– IL-1Ra^–/– BM cells (T^–/–Ra^–/– Δ WT); diamonds, WT or heterozygous (IL-1Ra^+/–) mice transferred with IL-1Ra^–/– BM cells (Ra^–/– Δ WT). (D) Incidence of arthritis in TNF-α^–/– IL-1Ra^–/– or IL-1Ra^–/– BM cell_transferred IL-1Ra^–/– mice. Squares, IL-1Ra^–/– mice transferred with TNF-α^–/– IL-1Ra^–/– BM cells (T^–/–Ra^–/– Δ Ra^–/–); circles, TNF-α^–/– IL-1Ra^–/– mice transferred with IL-1Ra^–/– BM cells (Ra^–/– Δ T^–/–Ra^–/–).