Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice
J. Clin. Invest. Xiuwei Tang, et al. 113:867 doi:10.1172/JCI20732 [
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Figure 3Effects of AZ overexpression on the development of UVB-induced tumors in the skin of wild-type and
Ptch1+/– mice. (A) Effects of AZ overexpression on the number of UVB-induced tumors. (B) Wild-type and
Ptch1+/– normal and AZ-overexpressing mice chronically exposed to UVB. (C) Volume of UVB-induced macroscopic tumors. *
P < 0.008 vs.
Ptch1+/–. **
P < 0.05 vs.
Ptch1+/+. (D) Effects of AZ overexpression on the area of UVB-induced microscopic BCC-like lesions. (E) Effects of AZ overexpression on the number of UVB-induced microscopic BCC-like lesions. (F) Histology of skin showing staining for β-gal (blue) in BCC-like lesions.
