Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1^+/– mice
J. Clin. Invest. Xiuwei Tang, et al. 113:867 doi:10.1172/JCI20732 [Go to this article.]

Figure 1
Ptch1+/+ heterozygous mice overexpressing ODC (Ptch1+/–/ODC TgN mice). (A) Ptch1+/– heterozygous mouse. (B) Ptch1+/– heterozygous mouse showing skull abnormality. (C) Ptch1+/–/ODC TgN mouse. (D) Ptch1+/^–/ODC TgN mouse showing skull abnormality. (E) Ptch1+/–/ODC TgN mouse at week 10. (F) Ptch1+/–/ODC TgN mouse at week 30. (G) UVB-irradiated Ptch1+/–/ODC TgN mouse at week 10. (H) UVB-irradiated Ptch1+/^–/ODC TgN mouse at week 20. (I) UVB-irradiated Ptch1+/–/ODC TgN mouse at week 30