Michael Nardi, Steven J. Feinmark, Liang Hu, Zongdong Li, Simon Karpatkin
J Clin Invest.
2004;
113(7):973–980
doi:10.1172/JCI20726
This article Copyright © 2004, The American Society for Clinical Investigation
Abstract
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ntiplatelet GPIIIa49–66 Ab of HIV-related thrombocytopenic patients induces thrombocytopenia and platelet fragmentation by the generation of peroxide and other reactive oxygen species (ROS). Here we report the presence of a functional platelet NADPH oxidase pathway that requires activation by the platelet 12-lipoxygenase (12-LO) pathway to fragment platelets. A new Ab-mediated mechanism is described in which the platelet 12-LO product, 12(S)-HETE activates the NADPH oxidase pathway to generate ROS.
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