Pedigrees and haplotyping of families B and C. The symbols denote the following: open squares, unaffected males; open circles, unaffected females; open diamonds, an additional number of unaffected siblings; slashed symbols, unexplained infant deaths; triangle, miscarriages; black symbols, affected children. The homozygous regions in the probands are indicated by rectangles. The polymorphic marker shown in italics is not part of the original 5-cM genome-wide scan marker set. (A) Family B pedigree and the chromosome 5 haplotype of the affected child. (B) Family C pedigree and the chromosome 5 haplotype shared by the affected siblings.