Erik Storkebaum, Peter Carmeliet
J Clin Invest.
2004;
113(1):14–18
doi:10.1172/JCI20682
This article Copyright © 2004, The American Society for Clinical Investigation
Abstract
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EGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neurodegenerative disorders.
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