Body weight gain of syndecan-3^–/– and wild-type mice on LF (11% fat) and HF (41% fat) diets. (A and B) Male (A) and female (B) syndecan-3^–/– (–/–) and wild-type (+/+) mice (n = 6–10 in each group) were given ad libitum access to diets for 14 weeks (*P < 0.05, repeated-measures two-way ANOVA; gene-diet-sex interaction, –df = (1, 50); F = 7.72; P = 0.007).