PPARα governs glycerol metabolism
J. Clin. Invest. David Patsouris, et al. 114:94 doi:10.1172/JCI20468 [Go to this article.]

Figure 2
PPARα upregulates the expression of numerous genes involved in the conversion of glycerol to glucose. (A) Relative expression of glycerol kinase (Gyk), cGPDH, mGPDH, AQP3, and AQP9 were determined by Q-PCR in fed and 24-hour-fasted wild-type and PPARα-null mice. Statistically significant effects were observed by two-way ANOVA for all genes for genotype (P < 0.01), and for the interaction between genotype and feeding status (P < 0.05). (B) Relative expression of Gyk, cGPDH, mGPDH, AQP3, and AQP9 were determined by Q-PCR in wild- type and PPARα-null mice after feeding with Wy14643. Statistically significant effects were observed by two-way ANOVA for all genes for genotype and for Wy14643 treatment, and for the interaction between the two parameters (P < 0.01), except for AQP9. Error bars represent SEM.