PPARα governs glycerol metabolism
J. Clin. Invest. David Patsouris, et al. 114:94 doi:10.1172/JCI20468 [Go to this article.]

Figure 1
Oligonucleotide microarray analysis identifies novel putative PPARα target genes. (A) Relative expression of PPARα in liver was determined by Q-PCR in fed and 24-hour-fasted mice (n = 4). The difference was evaluated by Student’s t test (P < 0.01). Error bars represent SEM. (B) Expression of genes involved in fatty acid oxidation and ketogenesis in livers of wild-type and PPARα-null mice, as determined by oligonucleotide microarray (Affymetrix). The average difference (expression) of wild-type at 0 hours was arbitrarily set at 100. Filled diamonds: long-chain fatty acyl-CoA synthetase; open diamonds: carnitine palmitoyltransferase II; filled triangles: long-chain acyl-CoA dehydrogenase; open circles: short-chain acyl-CoA dehydrogenase; open triangles: medium-chain acyl-CoA dehydrogenase; filled circles: dodecenoyl-CoA δ-isomerase; filled squares: HMG-CoA synthase; open squares: HMG-CoA lyase. (C) Hepatic expression of PEPCK (left), cGPDH (middle) and mGPDH (right) after 0, 2.5, 5.5 and 24 hours fasting in wild-type and PPARα-null mice according to oligonucleotide microarray. The average difference (expression) of wild-type at 0 hours was arbitrarily set at 100.