Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension
J. Clin. Invest. José M. Fernández-Fernández, et al. 113:1032 doi:10.1172/JCI20347 [
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Figure 2BK channel currents obtained from different combinations of α and β
1 BK channel subunits. Currents were recorded from excised inside-out macropatches obtained from HEK-293 cells expressing the BK α subunit (A), α+β
1WT (B), α+β
1E65K (C), or α+β
1WT+β
1E65K (D). Currents were recorded at 0.1 μM (left panels), 1.6 μM (middle panels), and 10 μM cytosolic Ca
2+ (right panels). The voltage protocol was as described in Methods.
