The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies
J. Clin. Invest. Irma Airoldi, et al. 113:1651 doi:10.1172/JCI20303 [
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Figure 5Characterization of
IL-12Rβ
2_transfected cells. (
A) Expression of
IL-12Rβ
2 mRNA in
IL-12Rβ
2 and empty-vector_transfected Raji and RPMI 8866 cells. From left to right: molecular weight markers; negative control, represented by a Th2 clone; positive control (tonsil B cells); Raji cells transfected with the empty vector (vector) or with the
IL-12Rβ
2_containing vector (IL-12Rβ2); RPMI 8866 cells transfected with the empty vector or with the
IL-12Rβ
2_containing vector. (
B) Induction of IFN-γ mRNA in Raji cells transfected with the empty vector or with the
IL-12Rβ
2_containing vector after treatment with IL-12 for 36 hours.
