Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
J. Clin. Invest. Donna Woulfe, et al. 113:441 doi:10.1172/JCI20267 [
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Figure 2Platelet aggregation. (
a) A representative aggregation tracing is shown for each agonist and genotype tested. (
b) The maximum extent of aggregation observed in response to increasing doses of AYPGQV was compared in WT versus
Akt2–/– mice. Each point is the mean ± SEM of two to six experiments (*
P < 0.05 and **
P < 0.005 using a paired Student’s
t test; number of experiments
n is shown in parentheses above each data point). conc, concentration.
