Isoform-specific regulation of mood behavior and pancreatic β cell and cardiovascular function by L-type Ca2+ channels
J. Clin. Invest. Martina J. Sinnegger-Brauns, et al. 113:1430 doi:10.1172/JCI20208 [
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Figure 5BayK-induced changes in motor disability grade in WT and
Cav1.2DHP–/– mice. WT (closed circles,
n = 5) or
Cav1.2DHP–/– (open circles,
n = 5) mice were injected subcutaneously with 2 mg/kg BayK and placed singly in 20 cm ∞30 cm clear plastic cages. They were then observed for 1 minute each at 5-minute intervals. Motor disability was rated at each timepoint on a 4-point scale according to Jinnah et al. (
8). No motor symptoms or abnormal behavior were observed after injection of vehicle alone.