Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport
J. Clin. Invest. Fatima Ferreirinha, et al. 113:231 doi:10.1172/JCI20138 [Go to this article.]

Figure 6
Early mitochondrial abnormalities in synaptic terminals of paraplegin-deficient mice. (a and b) Cross sections of the gray matter of the lumbar spinal cord from 4.5-month-old Spg7–/– mice showing nerve terminals. Enlarged mitochondria with indistinct and damaged cristae are present (arrows). (c and d) Comparable sections from age-matched control mice show typical terminal profiles with many synaptic vesicles and normal mitochondria (arrows). Bar: 0.5 μm.