Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport
J. Clin. Invest. Fatima Ferreirinha, et al. 113:231 doi:10.1172/JCI20138 [
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Figure 2Behavioral phenotype of paraplegin-deficient mice. (
a) The weights of
Spg7–/– mice are reduced compared with control mice beginning at 12 months of age (*
P < 0.01). Performance of
Spg7+/– and
Spg7–/– mice on an accelerating rotating rod apparatus at 2 months (
b), 4 months (
c), 7 months (
d), 12 months (
e), and 17 months (
f).
Spg7–/– animals showed impaired performance compared with heterozygous age-matched animals beginning at 4 months of age. Repeated-measures ANOVA confirmed a significant genotype effect (heterozygous versus knockout) at 4 months of age (
P < 0.005) and at 7, 12, and 17 months of age (
P < 0.00001). T, trial.
