Selectin and selectin ligand binding: a bittersweet attraction
J. Clin. Invest. Thomas M. Zollner, et al. 112:980 doi:10.1172/JCI19962 [
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Figure 1The multistep process of the interactions between lymphocytes and endothelial cells leading to T cell migration into skin. Selectin and selectin ligand interactions allow lymphocyte rolling along the endothelial lining. Lymphocyte chemokine receptors thereby come into contact with chemokines displayed by the endothelium; e.g., via proteoglycans leading to activation of integrins. This is necessary for subsequent firm adhesion of lymphocytes to the endothelium and the final transmigration through the blood vessel wall. VLA-4, very late antigen-4.
