Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure
J. Clin. Invest. Masaaki Hayashi, et al. 113:1138 doi:10.1172/JCI19890 [Go to this article.]

Figure 4
Histopathological analyses of pIpC-treated BMK1-CKO mice. (A) Histological analysis of BMK1-CKO hearts and pulmonary arteries at various time points after pIpC treatment. (B) Immunohistochemical analysis of control heart (left) and BMK1-CKO heart (right) with the CD31 Ab. (C) Immunofluorescent analysis of control heart (left) and BMK1-CKO heart (right) with Ab against smooth muscle actin (green) with nuclear DAPI staining (pseudo-colored, red). Arrowheads indicate abnormal endothelial nuclei. Asterisks indicate coronary arteries. Scale bars: A and B, 10 μm; C, 5 μm.