Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure
J. Clin. Invest. Masaaki Hayashi, et al. 113:1138 doi:10.1172/JCI19890 [
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Figure 3Increased vascular leakage after ablation of BMK1. (A–D) Representative ears showing increased baseline leakage of Evans blue dye in BMK1-CKO mice, which are further enhanced after topical application of mustard oil. Evans blue dye (30 mg/kg in a volume of 100 μl) was injected into the tail vein of anesthetized mice. (E) Quantification of extravasated Evans blue dye. Baseline leakage was elevated in BMK1-CKO mice (black bars) as compared with control WT mice (white bars). Similarly, significant increase in vascular leakage of BMK1-CKO mice was observed after mustard oil treatment. Values are mean ± SEM;
n = 6 mice per group. *
P < 0.05.
