CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
J. Clin. Invest. John W. Scott, et al. 113:274 doi:10.1172/JCI19874 [Go to this article.]

Figure 3
(a and b) Binding of AMP (a) and ATP (b) to the GST–CBS1-4 fusion protein from γ2 and WPWS mutants. (c and d) Binding of AMP (c) and ATP (d) by the GST–CBS1-4 fusion proteins from γ1, γ2, and γ3. The methodology was as for Figure 1, except that data were fitted to a two-site Hill plot model: bound = 2 × [nucleotide]^h/(B_0.5^h + [nucleotide]^h).