CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
J. Clin. Invest. John W. Scott, et al. 113:274 doi:10.1172/JCI19874 [Go to this article.]

Figure 2
Displacement of AMP from the CBS1-2 construct by ATP. A fixed concentration of [¹⁴C]AMP (180 μM) was incubated with the CBS1-2 construct in the presence of increasing concentrations of ATP. Data were fitted to the binding model: bound = AMP/[AMP + K_dAMP(1 + [ATP]/K_dATP)].