Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia)
J. Clin. Invest. Bindu M. Nair, et al. 113:464 doi:10.1172/JCI19710 [Go to this article.]

Figure 2
Drug accumulation in isogenic strains with and without the efflux gene cluster. Energy-dependent efflux of [3H]chloramphenicol (a) and [14C]salicylate (b) by B. cepacia. Strains 249-2(pAM1) (filled squares) and 249-2(pSP329) (open circles) were assayed for accumulation of radiolabel before and after the addition of 250 μM CCCP. The addition of CCCP increased cell-associated accumulation of both drugs (i.e., decreased drug efflux) in 249-2(pAM1). Data points represent the means of three experiments with error bars showing the SD.