Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses
J. Clin. Invest. Akira Yamaguchi, et al. 113:200 doi:10.1172/JCI19639 [
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Figure 8Reduction of apoptosis in the brain of
Hexb–/–FcRγ–/– mice. (
a) At 14 weeks,
Hexb–/–FcRγ–/– mice were analyzed by in situ TUNEL analysis, and compared with
Hexb–/–FcRγ+/+ and
Hexb+/+FcRγ+/+ mice. Arrows indicate apoptotic cells. Original magnification, ×100 (thalamus). (
b) Numbers of apoptotic (TUNEL positive) cells were counted in a sagittal section of the brain. Data are mean ± SEM (
n = 4). *
P < 0.001, Student’s
t test. (
c) DNA laddering in the brain from
Hexb+/+FcRγ+/+,
Hexb–/–FcRγ–/–, and
Hexb–/–FcRγ+/+ mice. One microgram of brain DNA was subjected to electrophoresis on a 2% agarose gel and stained with ethidium bromide. The lane at the left of the panel shows a 1-kb DNA ladder.
