Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses
J. Clin. Invest. Akira Yamaguchi, et al. 113:200 doi:10.1172/JCI19639 [
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Figure 3Generation of
Hexb–/–FcRγ–/– mice. (
a) PCR analysis of mouse tail DNA. From left lane:
Hexb+/+FcRγ+/+,
Hexb–/–FcRγ+/+,
Hexb–/–FcRγ+/–, and
Hexb–/–FcRγ–/– mice. (
b) Clinical appearance of
Hexb–/–FcRγ+/+ and
Hexb–/–FcRγ–/– mice at 14 weeks. (
c) Investigation of the titers of anti-GA2 antibodies in 14-week-old mice. Anti-GA2 antibody was at lower levels in
Hexb–/–FcRγ–/– mice than in
Hexb–/–FcRγ+/+ mice.
n = 5–10. *
P < 0.05, Student’s
t test.
