A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression
J. Clin. Invest. Janete M. Cerutti, et al. 113:1234 doi:10.1172/JCI19617 [
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Figure 3Immunohistochemical analysis of DDIT3 (A–F) and ARG2 (G–L) in paraffin-embedded sections of FTAs and FTCs. FTCs exhibited strong brown immunostaining for DDIT3 (D–F) and ARG2 (J–L). In contrast, FTAs (A–C and G–I) exhibited no immunoreactivity. The arrows in D and F show the vascular invasion in FTCs and the follicular cells that are positive for DDIT3. The arrow in L shows the normal thyroid tissue that was negative for ARG2, adjacent to tumor area that was positive for ARG2. Hematoxylin was used as a nuclear counterstain. Original magnification, ×100 for A–E and G–L, ×40 for F.
